SHAO LAB

^ Equal Contribution

* Corresponding Author

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45. Pan S^, Ding A^, Li Y, Sun Y, Zhan Y, Ye Z, Song N, Peng B, Li L*, Huang W*, Shao H*

Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine.

Chemical Society Reviews, 52, 5706-5743 (2023).

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44. Zhang Y^, Wong CY^, Lim CZJ^, Chen Q, Yu Z, Natalia A, Wang Z, Pang QY, Lim SW, Loh TP, Ang BT, Tang C, Shao H*

Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors.

Nature Communications, 14, 4278 (2023).

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43. Natalia A^, Zhang L^, Sundah NR, Zhang Y, Shao H*

Analytical device miniaturization for the detection of circulating biomarkers.

Nature Reviews Bioengineering, 1, 481-498 (2023).

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42. Zhao H^, Pan S^, Natalia A, Wu X, Ong C-AJ, Teo MCC, So JBY, Shao H*

A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples.

Nature Biomedical Engineering, 7, 135-148 (2022).

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41. Zhao H^, Zhang Y^, Chen Y, Ho NRY, Sundah NR, Natalia A, Liu Y, Miow QH, Wang Y, Tambyah PA, Ong CWM, Shao H*

Accessible detection of SARS-CoV-2 through molecular nanostructures and automated microfluidics.

Biosensors and Bioelectronics, 194, 113629 (2021).

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40. Chen Y^, Sundah NR^, Ho NRY^, Natalia A, Liu Y, Miow QH, Wang Y, Beh DLL, Chew KL, Chan D, Tambyah PA, Ong CWM, Shao H*

Collaborative Equilibrium Coupling of Catalytic DNA Nanostructures Enables Programmable Detection of SARS-CoV-2.

Advanced Science, 8, 2101155 (2021).

Featured as frontispiece.

 

39. Wang Z, Zhao H, Zhang Y, Natalia A, Ong C-AJ, Teo MCC, So JBY, Shao H*

Surfactant-guided spatial assembly of nano-architectures for molecular profiling of extracellular vesicles.

Nature Communications, 12, 4039 (2021).

 

38. Sundah NR^, Natalia A^, Liu Y^, Ho NRY, Zhao H, Chen Y, Miow QH, Wang Y, Beh DLL, Chew KL, Chan D, Tambyah PA, Ong CWM, Shao H*

Catalytic amplification by transition-state molecular switches for direct and sensitive detection of SARS-CoV-2.

Science Advances, 7, 12, eabe5940 (2021).

 

37. Pan S^, Zhang Y^, Natalia A, Lim CZJ, Ho NRY, Chowbay B, Loh TP, Tam JKC, Shao H*

Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy.

Nature Nanotechnology, 16, 734-742 (2021).

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36. Lim CZJ^, Natalia A^, Sundah NR, Shao H*

Biomarker Organization in Circulating Extracellular Vesicles: New Applications in Detecting Neurodegenerative Diseases.

Advanced Biosystems, 1900309 (2020).

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35. Wu X^, Zhao H^, Natalia A, Lim CZJ, Ho NRY, Ong C-AJ, Teo MCC, So JBY, Shao H*

Exosome-templated nanoplasmonics for multiparametric molecular profiling.

Science Advances, 6, 19, eaba2556 (2020).

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34. Lim CZJ, Zhang L, Zhang Y, Sundah NR, Shao H*

New Sensors for Extracellular Vesicles: Insights on Constituent and Associated Biomarkers.

ACS Sensors, 5, 1, 4-12 (2020).

Featured as cover.

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33. Wang Z, Sun X, Natalia A, Tang CSL, Ang CBT, Ong C-AJ, Teo MCC, So JBY, Shao H*

Dual-Selective Magnetic Analysis of Extracellular Vesicle Glycans.

Matter, 2, 150-166 (2020).

 

32. Sundah NR, Ho NRY, Lim GS, Natalia A, Ding X, Liu Y, Seet JE, Chan CW, Loh TP, Shao H*
Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution.
Nature Biomedical Engineering, 3, 684-694 (2019).
Featured in News & Views.
Featured as cover.
 

31. Balaji AN^, Chen Y^, Wang B, Peh L-S*, Shao H*
pH Watch – Leveraging Pulse Oximeters in Existing Wearables for Reusable, Real-time Monitoring of pH in Sweat.
MobiSys: Proceedings of the 17th Annual International Conference on Mobile Systems, Applications, and Services, 262-274 (2019).
 

30. Lim CZJ^, Zhang Y^, Chen Y, Zhao H, Stephenson MC, Ho NRY, Chen Y, Chung J, Reilhac A, Loh TP, Chen CLH, Shao H*
Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition.
Nature Communications, 10, 1144 (2019).
Featured as an Editors’ Highlight.
 

29. Lim GS^, Hor JH^, Ho NRY, Wong CY, Ng SY, Soh BS*, Shao H*
Microhexagon gradient array directs spatial diversification of spinal motor neurons.
Theranostics, 9, 311-323 (2019).
 

28. Chen Y, Ding X, Zhang Y, Natalia A, Sun X, Wang Z, Shao H*
Design and synthesis of magnetic nanoparticles for biomedical diagnostics
.
Quantitative Imaging in Medicine and Surgery, 8, 957 (2018). (Invited manuscript)
 

27. Ho NRY^, Lim GS^, Sundah NR, Lim D, Loh TP, Shao H*
Visual and modular detection of pathogen nucleic acids with enzyme-DNA molecular complexes.
Nature Communications, 9, 3238 (2018).
Featured as an Editors’ Highlight.
 

26. Shao H, Im H, Castro CM, Breakefield XO, Weissleder R, Lee H
New technologies for analysis of extracellular vesicles.
Chemical Reviews, 118, 1817-1950 (2018).
 

25. Wang L, Meng Z, Martina F, Shao H, Shao F
Fabrication of circular assemblies with DNA tetrahedrons: from static structures to a dynamic rotary motor.
Nucleic Acids Research, 45, 12090-12099 (2017).
 

24. Shao H*, Chung J, Issadore D
Diagnostic technologies for circulating tumor cells and exosomes.
Bioscience Reports, 36, e00292 (2016). (Invited manuscript)
 

23. Shao H^, Chung J^, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H, Weissleder R
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.
Nature Communications, 6, 6999 (2015).
Featured as research highlight of the journal.
 

22. Im H^, Castro CM^, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R, Lee H
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.
Proc Natl Acad Sci USA, 122, 5613-5618 (2015).
 

21. Im H, Shao H, Weissleder R, Castro CM, Lee H
Nano-plasmonic exosome diagnostics.
Expert Rev Mol Diagnostics, 15, 725-733 (2015).
 

20. Lee K, Shao H, Weissleder R, Lee H
Acoustic purification of extracellular microvesicles.
ACS Nano, 9, 2321-2327 (2015).
 

19. Im H^, Shao H^, Park Y, Peterson VM, Castro CM, Weissleder R, Lee H
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor.
Nature Biotechnology, 32, 490-495 (2014).
Featured as one of the greatest hits in 20 years of Nature Biotechnology biomedical research.
 

18. Issadore D, Park Y, Shao H, Min C, Lee K, Liong M, Weissleder R, Lee H
Magnetic sensing technology for molecular analyses.
Lab on a Chip, 14, 2385-2397 (2014).
 

17. Yoon TJ, Shao H, Weissleder R, Lee H
Oxidation kinetics and magnetic properties of elemental iron nanoparticles.
Part Part Syst Charact, 30, 667-671 (2013).
 

16. Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H
Magnetic nanosensor for detection and profiling of erthyrocyte-derived microvesicles.
ACS Nano, 7, 11227-11233 (2013).
 

15. Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H
Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.
Lab on a Chip, 14, 14-23 (2013).
 

14. Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.
Nature Medicine, 18, 1835-1840 (2012).
Featured by BBC News, recommended by Faculty of 1000, and research highlighted in:
– Editors’ Choice: Warranted wiretapping: listening in on cancer’s conversations. Sci Transl Med 4, 164ed224 (2012).
– Glioblastoma: microvesicles as major biomarkers. Nat Rev Cancer 13, 8 (2013).
– Biomarkers: nanotechnology opens up new realm of detection in GBM. Nat Rev Clin Oncol 10, 4 (2013).
– Glioblastoma detection and therapy monitoring by microvesicle release. Nat Rev Neurol 9, 4 (2013).
 

13. Chung J^, Shao H^, Reiner T, Issadore D, Weissleder R, Lee H
Cell sorting: microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.
Advanced Healthcare Materials, 1, 432-436 (2012).
Featured as cover.
 

12. Issadore D, Chung J^, Shao H^, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H
Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.
Science Translational Medicine, 4, 141ra92 (2012).
Featured as cover.
 

11. Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H
Mechanism of magnetic relaxation switching sensing.
ACS Nano, 6, 6821-6828 (2012).
 

10. Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H
Magnetic nanoparticles and microNMR for diagnostic applications.
Theranostics, 2, 55-65 (2012).
 

9. Yoon TJ^, Lee H^, Shao H, Hilderbrand SA, Weissleder R
Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles.
Advanced Materials, 23, 4793-4797 (2011).
 

8. Yoon TJ^, Lee H^, Shao H, Weissleder R
Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
Angew Chem Int Ed Engl, 50, 4663-4666 (2011).
 

7. Erathodiyil N, Gu H, Shao H, Jiang J, Ying JY
Enantioselective hydrogenation of a-ketoesters over alkaloid-modified platinum nanowires.
Green Chemistry, 13, 3070-3074 (2011).
 

6. Mao J, Cao X, Zhen J, Shao H, Gu H, Lu J and Ying JY
Facile synthesis of hybrid nanostructures from nanoparticles, nanorods and nanowires.
Journal of Materials Chemistry, 21, 11478-11481 (2011).
 

5. Shao H, Yoon TJ, Liong M, Weissleder R, Lee H
Magnetic nanoparticles for biomedical NMR-based diagnostics.
Beilstein Journal of Nanotechnology, 1, 142-154 (2010).
 

4. Liong M, Shao H, Haun JB, Lee H, Weissleder R
Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.
Advanced Materials, 22, 5168-5172 (2010).
 

3. Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H
Self-assembled magnetic filter for highly efficient immunomagnetic separation.
Lab on a Chip, 11, 147-151 (2010).
 

2. Jiang J, Gu H, Shao H, Devlin E, Papaefthymiou GC, Ying JY

Bifunctional Fe3O4-Ag heterodimer nanoparticles for two-photon fluorescence imaging and magnetic manipulation.
Advanced Materials, 20, 4403-4407 (2008).

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1. Zhao J, Wu J, Shao H, Kong F, Jain N, Hunt G, Feigenson GW
Phase studies of model biomembranes: macroscopic coexistence of La and Lb, with light-induced coexistence of La + Lo phases.
Biochim Biophys Acta, 1768, 2777-2786 (2007).